Pregabalin

Pregabalin is an anticonvulsant approved in human medicine for the treatment of neuropathic pain, epilepsy and generalised anxiety disorders. In veterinary medicine, it is used in dogs when other painkillers or antiepileptics are not sufficiently effective.

Use in dogs takes place under strict veterinary supervision and is significantly rarer than in human medicine.

What is pregabalin and what is it used for?

Pregabalin dampens the activity of certain nerves in the central nervous system. Thereby it relieves pain and reduces the frequency of seizures. In dogs, pregabalin is used primarily in two situations:

• Neuropathic pain: The medication can help with chronic nerve pain caused, for example, by herniated discs, nerve damage or degenerative diseases of the nervous system.
• Seizures: Pregabalin is used as an adjunctive therapy when other antiepileptics such as phenobarbital or levetiracetam do not adequately control seizures.

Dosage and form of administration

The dosage is based on weight, the type and severity of the condition, as well as the individual response of the dog. The vet adjusts the dose accordingly.

Pregabalin is usually administered in the form of capsules or tablets.

Side effects and precautions

Dogs may show the following side effects:

• Drowsiness or sedation
• Coordination disorders
• Dizziness
• Vomiting or loss of appetite
• Weight gain

Close veterinary monitoring is necessary due to the potential for side effects and overdose.

Important: Pregabalin must not be stopped abruptly, as this can lead to withdrawal symptoms. A gradual tapering under veterinary guidance is required.

The medication can interact with other drugs. The vet should therefore be informed about all medications the dog receives.

Note: In Switzerland, pregabalin is not a first-line medication in veterinary medicine. It is only used in special cases when other treatment approaches are insufficient.